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World Parkinson's Day 2024: Understanding how the degenerative brain condition impacts cardiac function

Parkinson's Disease and Heart Troubles: A Complex Connection

Parkinson's disease, a common neurodegenerative disorder, significantly impacts quality of life. Dr. Ajit Menon, a cardiologist, highlights the link between Parkinson's and heart problems.

Parkinson's and the Autonomic Nervous System:

Patients with Parkinson's often experience autonomic nervous system dysregulation. This disrupts blood pressure control, leading to:

  • Orthostatic hypotension: Sudden blood pressure drop upon standing from sitting or lying down, causing dizziness or fainting.
  • Postprandial hypotension: Blood pressure drop after meals.
  • Diastolic dysfunction: Difficulty relaxing the heart muscle, leading to shortness of breath.

Medications and Heart Risks:

Some Parkinson's medications, like levodopa and anticholinergics, can worsen these issues by:

  • Further impacting blood pressure control during position changes.
  • Causing ventricular arrhythmias (irregular heartbeats).

Silent Hypertension and Inflammation:

People with Parkinson's may also experience:

  • Blunted nighttime blood pressure dip: This worsens the effects of high blood pressure.
  • Increased vascular inflammation: This contributes to heart disease.
  • Insulin resistance and altered cholesterol levels: These are additional risk factors for heart problems.

The Overall Impact:

These factors combine to increase the risk of:

  • Ischemic heart disease: Blocked arteries in the heart.
  • Cardiomyopathies: Weakened heart muscle.
  • Arrhythmias: Irregular heartbeats.
  • Sudden cardiac death (possible, but not definitively linked).

While the exact mechanisms aren't fully understood, this highlights the importance of managing both Parkinson's and heart health for patients.

April 20, 2024 12:34 a.m. 131

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